In ulcerative colitis uc, the inflammation is localized in the colon, and one of the successful strategies for colontargeting drug delivery is the prodrug approach. Nanoparticlebased oral drug delivery systems targeting the. We aim to use the phospholipase a2 pla2, an enzyme that is overexpressed in the inflamed colonic tissues of. Apart from retarding or targeting dosage forms, a reliable colonic drug delivery could also be an important starting position for the colonic absorption of perorally applied, undigested, unchanged and fully active peptide drugs. Nov 21, 2017 colon targeting colonic drug delivery uses pharmacology study material project thesis title pharmacology lectures for pharmacy students pharmacology easy notes, kaplan pharmacology lecture notes pdf, pharmacology lecture notes ppt, pharmacology notes for medical students. At least 50% of the dosage forms available in the market are oral dosage form because these system have more advantage due to high patient compliances akhil et al. Pharmaceutical approaches for targeting drugs to colon ph sensitive systems microbially triggered system prodrugs polysaccharide based systems timed release systems osmotically controlled drug delivery systems pressure dependent release systems an oral colonic delivery system should retard drug release in the stomach and small intestine but. To achieve successful colon targeted drug delivery, a drug need to be protected from degradation, release and absorption in. Formulations for colonic delivery are also suitable. Limitations of colon targeting drug delivery system multiple manufacturing steps.
To form the pharmacologically inactive prodrug, the parent drug is attached to a chemical group, and enzymatic degradation by the bacteria in the colon. Colonspecific drug delivery systems cdds are desirable for the treatment of a range of local diseases such as ulcerative colitis, crohns disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer. Jun 26, 2009 specific targeting of drugs to the colon is recognized to have several therapeutic advantages. Technology or design alone do not make a successful product. Colon targeting colonic drug delivery uses pharmacology study material project thesis title pharmacology lectures for pharmacy students pharmacology easy notes, kaplan pharmacology lecture notes pdf, pharmacology lecture notes ppt, pharmacology notes for medical students. This novel system comprises a mixture of phresponsive polymer eudragit s and biodegradable. Prodrug targeted drug delivery system include three components. The various strategies for targeting orally administered drugs to the colon include covalent linkage of a drug with a carrier, coating with phsensitive polymers, formulation of timed released systems, exploitation of carriers that are degraded specifically by colonic bacteria, bioadhesive systems and osmotic controlled drug delivery systems. Pdf targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis. In this work, we present a novel phospholipid plbased prodrug approach, as a tool for colonic drug targeting in uc. In addition, the colon can be a potential site for the systemic absorption of several drugs to treat noncolonic conditions. Formulation and evaluation of colon targeted drug delivery of. Feb 27, 2016 pharmaceutical approaches for targeting drugs to colon ph sensitive systems microbially triggered system prodrugs polysaccharide based systems timed release systems osmotically controlled drug delivery systems pressure dependent release systems an oral colonic delivery system should retard drug release in the stomach and small intestine but. Free radical polymerization converts aqueous solutions of methacrylated inulin into crosslinked hydrogels.
Colonspecific drug delivery for mebeverine hydrochloride. Formulation and evaluation of colon targeted drug delivery system. This approach can be used in any dosage form such as tablets, capsules. Formulations for colonic delivery are also suitable for delivery of drugs which polar andor susceptible to chemical and enzymatic degradation in the upper gi tract, highly affected by hepatic metabolism, in particular, therapeutic proteins and peptides. Treatment of colon can be made effective if the drug can be targeted directly into the colon because drug release and absorption should not be take in abdomen and the small intestine and bioactive agents should not be degraded and to allow drug release into the colon. Introduction delivery of a drug to a specific organ or tissue i. Drug delivery to the colon relies on a number of physiological factors to ensure optimal efficacy following oral administration.
Colon targeting has gained increasing importance for the topical treatment of diseases of the colon, such as crohns disease, ulcerative colitis, colorectal cancer and amebiasis. Pdf day by day there are new developments in field of colon specific drug delivery system. A novel coating concept for ileocolonic drug targeting. Therapeutic advantages of targeting drug to the diseased organ includes1,2 a the ability to cut down the conventional dose b reduced the incidence of adverse site effects c delivery of. Colon targeting colonic drug delivery uses pharmacology study material project thesis title pharmacology lectures for pharmacy students pharmacology easy notes, kaplan pharmacology lecture notes pdf, pharmacology lecture notes ppt. The resident microflora could also affect colonic performance via metabolic degradation of the drug. Review article colon targeted drug delivery using different approaches sharma anuj, jain k amit address for correspondence department of pharmaceutics b. Ithydrogel drug delivery platform also holds promise in future as a targeted enemabased therapy in patients with colonic ibd. The factor which involve physiologically in drug delivery and responsible for affecting the targeting of drug to the colon are. Incomplete release of drug bioavailability of drug may be low due to potentially binding of drug in a. A successful and precise colon drug delivery system requires a drug to be.
Colon targeted drug delivery systems linkedin slideshare. Nanoarchitectonics for smart delivery and drug targeting. The colon targeted drug delivery has a number of important implications in the field of pharmacotherapy. Introduction targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, crohns disease, amebiosis, colonic cancer, local treatment of colonic pathologies, and systemic delivery of protein and peptide drugs. Drug targeting to the colonic area is not only associated with the treatment. In ph controlled release systems, the different ph of human git is exploited by coating the dosage form with ph dependent polymers which remains as such in the upper git and degrade in the large intestine where the ph is high i. The pellet cores were coated to different film thicknesses with. The prodrug strategy exploits the presence of the colonic microflora, which is in the order of 10 11 10 12 colonyforming unit cfu per ml in the colon, compared with 10 3 10 4 cfuml in the stomach and small intestine 2. Review article colon targeted drug delivery systems.
Colonic drug delivery has gained increased importance not. Treatment could be enhanced when drug delivered to the target site on the colon. Day by day there are new developments in field of colon specific drug delivery system. Oral colon targeted drug delivery systems have recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration. Advances in oral nanodelivery systems for colon targeted. Among all, a new concept in colonic drug targeting introduced by combining ph responsive and bacterially triggered mechanisms in a single layer matrix film figure 4. To deliver the compounds in a nondegraded form to the lower part of the gastrointestinal tract, they must first of all pass through the stomach, the upper part of the intestine and must use the characteristics of the colon to specifically release. Background current approaches to colonic drug delivery exploit one of two main physiological characteristics. Drugs which are destroyed by the stomach acid andor metabolized by pancreatic enzymes are slightly affected in the colon, and sustained colonic release of drugs can be useful in the treatment of nocturnal asthma, angina and arthritis.
Pdf inulin hydrogels as carriers for colonic drug targeting. Emerging techniques and challenges in colon drug delivery. Colon targeted drug delivery systems a potential approach. M college of pharmacy, bahadurgarh, haryana, india day by day there are new developments in field of colon specific drug delivery system. In the case of colonic drug targeting, delivery is intrinsically dependent upon the use of such polymer coatings in order to circumvent conditions in the stomach and small intestine. Current approaches to colonic drug delivery mainly utilise one of two intestinal characteristics. Many other researchers have also been challenging the same subject. Local delivery could, for example, allow topical treatment of inflammatory bowel disease ibd. Oral drug delivery being the most convenient method for colonspecific targeting and the treatment of ibd, qiao et al.
This approach shows promising results in the colon drug delivery system as it. Colon specific drug delivery system linkedin slideshare. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the. Two basic approaches may be taken in delivering drugs to the colon. Colon targeted drug delivery systems a potential approach nishant singh and dr. Colon targeting has gained increasing importance for the topical treatment of diseases of the colon. Additional interest in colon targeted drug delivery system has generated from the potential of the colonic site for the entry of some drugs into the systemic circulation. Colon targeted drug delivery system a novel perspective by bhushan prabhakar kolte.
Sep 17, 2012 targeting drugs and delivery systems to the colonic region of the gastrointestinal tract has received considerable interest in recent years. Jun, 2015 colonspecific drug delivery systems cdds are desirable for the treatment of a range of local diseases such as ulcerative colitis, crohns disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer. Vinyl groups were introduced in inulin chains in order to form hydrogels of this sugar polymer by free radical polymerization. Targeting of drugs to the colon via oral administration protect the drug. Integrated drug delivery for ulcerative colitis treatment. Pdf role of natural polymers in the development of. Strategic approaches for colon targeted drug delivery mdpi.
Therapeutic advantages of targeting drug to the diseased organ includes1,2 a the ability to cut down the conventional dose b reduced the incidence of adverse site effects c delivery of drug in its intact form as close as possible to the target sites. These approaches involve the use of formulation components that interact with one or more. Nanoparticlebased oral drug delivery systems targeting. Formulation and evaluation of colon targeted drug delivery. Polymers for colon targeted drug delivery article pdf available in indian journal of pharmaceutical sciences 726. The author has been developed specific delivery systems of an antiinflammatory drug for. The various strategies for targeting orally administered drugs to the colon include covalent linkage of a drug with a carrier, coating with phsensitive polymers, formulation of timed released systems, exploitation of carriers that are degraded specifically by colonic. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon like crohns disease, ulcerative colitis, etc. Colonic delivery, 5aminosalicylic acid, pectin, chitosan, compression coating, pectinase. Drugs such as proteins and peptides that are known. Colonspecific drug delivery has gained increased importance for the delivery of drugs for the treatment of local diseases associated with the colon.
The colon is a site where local delivery allows topical treatment of inflammatory bowel disease and systemic delivery of. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the. Here, we describe a new concept in targeted delivery, which combines these triggers to improve colonic delivery. Recent developments in colon specific drug delivery. The colonic region is believed to contain lower levels of luminal and mucosal digestive enzymes in comparison with stomach and small intestine 8. Inulin was reacted with glycidyl methacrylate in n,ndimethylformamide in the presence of. Targeting drugs and delivery systems to the colonic region of the gastrointestinal tract has received considerable interest in recent years. A targeting strategy for colonic drug delivery introduction. Enteric coatings are widely used to delay the release of medicaments to the lower regions of the gastrointestinal tract.
This targeting of drug to the disease site lowers the. The purpose of this work was to study the hydrogel formation and to characterize the fully cured hydrogels. Colon specific drug delivery, ph sensitive, time controlled dependent, microbially d and osmotically controlled system. Scientific endeavour in this area has been driven by the need to better treat local disorders of the colon such as inflammatory bowel disease ulcerative colitis and crohns disease, irritable bowel syndrome and carcinoma. International journal of drug formulation and research 2010. Colon targeting colonic drug delivery uses pharmacology. Tfr expression was found to be elevated in the basolateral and apical membranes of enterocytes present in the colonic mucosa of patients with uc and in the colonocytes of rats with induced colitis. Targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, crohns disease, amebiosis, colonic cancer, local treatment of colonic pathologies, and systemic delivery of protein and peptide drugs. International journal of pharmaceutical sciences 2002. The colonic region is believed to contain lower levels of luminal and mucosal digestive enzymes in. From the invitro dissolution studies it can be discussed that the colon targeted matrix tablet containing 20% guar gum was the best formulation to target the nitrofurantoin to the colon. Phospholipidbased prodrugs for colontargeted drug delivery. Colon targeted drug delivery system ctdds delivered as both local and systemic delivery of drugs. The colon targeted drug delivery system is used for the treatment of various diseases related to colon like inflammatory bowel disease, crohns disease, colon cancer, etc.
Targeting of drugs to the colon via oral administration protect the drug from degradation or release in the stomach and small intestine. Local delivery could, for example, allow topical treatment of. Introduction drug delivery to the colon should be capable of protecting the drug en route to the colon i. Pharmaceutical approaches to colon targeted drug delivery. Therapeutic advantages of targeting drug to the diseased organ include.
Significance of ligandanchored polymers for drug targeting. From the invitro dissolution studies it can be discussed that the colon targeted matrix tablet containing 20% guar gum was the best formulation to. Colon targeted drug delivery system semantic scholar. Novel approaches to colon targeted drug delivery system.
The former involves sustained release dosage forms, which are designed to prolong drug dissolution and hence absorption, until it reaches the colon. Considerations should be made during formulation design to the residence time of the formulation in the gi tract, how the gi environment affects the delivery of the formulation and dissolution of the drug at the site of action, the intestinal fluid volume, and the. The in vivo proof of concept of a novel doublecoating system, based on enteric polymers, which accelerated drug release in the ileocolonic region, was investigated in humans. Colonic drug delivery has gained valued attention not just for the targeted delivery and effective therapy of local diseases associated with the colon but also for its potential for the delivery of proteins and therapeutic peptides. Colon targeted drug delivery system may be following the concept of control or sustained route for drug administration has received more attention vinay et al. Recent developments in colon specific drug delivery systems. Specific targeting of drugs to the colon is recognized to have several therapeutic advantages. In ulcerative colitis uc, the inflammation is localized in the colon, and one of the successful strategies for colon targeting drug delivery is the prodrug approach. Review article colontargeted oral drug delivery systems core. Colonic drug delivery drug candidate drugs which show poor absorption from the stomach as intestine including peptide are most suitable for cdds. Various strategies used for targeting drugs to the colon include formation of a prodrug, coating with time or phdependent polymers, use of colonspecific biodegradable polymers, osmotic systems and.
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